Coronavirus Background:
Coronaviruses are a large family of viruses that can cause illness in animals or humans. In humans there are several known coronaviruses that cause respiratory infections. These coronaviruses range from the common cold to more severe diseases such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19.

Coronavirus Disease 2019:
COVID-19 was identified in Wuhan, China in December 2019. COVID-19 is caused by the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a new virus in humans causing respiratory illness which can be spread from person-to-person. Early in the outbreak, many patients were reported to have a link to a large seafood and live animal market, however, later cases with no link to the market confirmed person-to-person transmission of the disease. Additionally, travel-related exportation of cases has occurred.

COVID-19 is primarily transmitted from person-to-person through respiratory droplets. These droplets are released when someone with COVID-19 sneezes, coughs, or talks. Infectious droplets can land in the mouths or noses of people who are nearby or possibly be inhaled into the lungs. A physical distance of at least 1 meter (3 ft) between persons is recommended by the World Health Organization (WHO) to avoid infection,1 whereas CDC recommends maintaining a physical distance of at least 1.8 meters (6ft) between persons. Respiratory droplets can land on hands, objects or surfaces around the person when they cough or talk, and people can then become infected with COVID-19 from touching hands, objects or surfaces with droplets and then touching their eyes, nose, or mouth. Recent data suggest that there can be transmission of COVID-19 through droplets of those with mild symptoms or those who do not feel ill2. Current data do not support long range aerosol transmission of SARS-CoV-2, such as seen with measles or tuberculosis. Short-range inhalation of aerosols is a possibility for COVID-19, as with many respiratory pathogens. However, this cannot easily be distinguished from “droplet” transmission based on epidemiologic patterns. Short-range transmission is a possibility particularly in crowded medical wards and inadequately ventilated spaces3. Certain procedures in health facilities can generate fine aerosols and should be avoided whenever possible.

A wide range of symptoms for COVID-19 have been reported4. These include:

Fever or chills
Shortness of breath or difficulty breathing
Nasal congestion or runny nose
Muscle or body aches
Sore throat
New loss of smell or taste
Nausea or vomiting
The estimated incubation period is between 2 and 14 days with a median of 5 days. It is important to note that some people become infected and do not develop any symptoms or feel unwell.

Illness Severity 5,6,7
Despite the important concerns about case fatality rates, most COVID-19 illnesses are – and we expect will continue to be – mild, and most patients will recover spontaneously with some supportive care, especially children and young adults. Data from several countries suggest that 14%-19% are hospitalized and 3%-5% will need intense care unit admission.

The first largest description of patients with COVID-19 came from China, where the outbreak of COVID-19 started, and is described in detail below. Among the 44,672 confirmed COVID-19 cases reported from December 31, 2019 through February 11, 2020, the clinical presentation was as follow:

Mild (non-pneumonia and mild pneumonia cases) represented 80.9% of confirmed patients with COVID-19 in China.

NOTE: These cases included a large spectrum of illnesses including but not limited to patients having fever, cough, chest pain, nausea, and body pain. Severe (dyspnea, respiratory frequency ≥ 30/min, blood O2 sat ≤93%, PaO2/FiO2 ratio <300, lung infiltrates >50% within 24–48 hours) represented 13.8% of confirmed patients with COVID-19 in China.

Critical (respiratory failure, septic shock, and/or multiple organ dysfunction or failure, death) represented 4.7% of confirmed patients with COVID-19 in China. 1,023 (49%) deaths were reported among the 2,087 critically ill patients.

People at Higher Risk for Severe Illness
It is important to note that COVID-19 is a new disease, therefore there is limited information regarding risk factors for severe disease. In some cases, people who get COVID-19 can become seriously ill and develop difficulty breathing. These severe complications can lead to death. The risk of severe disease increases steadily as people age. Additionally, those of all ages with underlying medical conditions (including but not limited to heart disease, diabetes, or lung disease) appear to be at higher risk in developing severe COVID-19 compared to those without these conditions. As more data become available, additional risk factors for severe COVID-19 may be identified.

COVID-19 Prevention and Treatment
COVID-19: Everyday Preventive Actions
There are a number of ways to prevent the spread of COVID-19 infection. These include:

Avoid touching your eyes, nose and mouth
Avoid close contact with people who are sick
Remember that some people without symptoms can still spread the virus
Stay at home when you are sick
Cover your cough or sneeze with a tissue, then dispose of it properly
Use a face covering when physical distancing is difficult or when going into closed spaces8
Physical distancing should be at least 1 meter (3 ft)
Clean and disinfect frequently touched objects and surfaces
Perform hand hygiene with soap and water or use alcohol-based hand rub
Hand Rub should contain at least 60% alcohol9
Hand washing should be done for at least 40-60 seconds based on WHO’s recommendations
COVID-19: Treatment
Currently, care for patients with COVID-19 is primarily supportive. Care is given to patients to help relieve symptoms and manage respiratory and other organ failure. There are currently no specific antiviral treatments licensed for COVID-19, however many treatments are under investigation. Remdesivir, which is also an investigational drug, received Food and Drug Administration (FDA) emergency use authorization for treatment of hospitalized patients.

IPC for COVID-19
What is IPC?
Infection prevention and control (IPC) is the practice of preventing or stopping the spread of infections during healthcare delivery in facilities like hospitals, outpatient clinics, dialysis centers, long-term care facilities, or traditional practitioners. IPC is a critical part of health system strengthening and must be a priority to protect patients and healthcare workers. In the context of COVID-19, the IPC goal is to support the maintenance of essential healthcare services by containing and preventing COVID-19 transmission within healthcare facilities to keep patients and healthcare workers healthy and safe.

COVID-19: IPC Priorities
Rapid identification of suspect cases
Screening/Triage at initial healthcare facility encounter and rapid implementation of source control
Limiting the entry of healthcare workers and/or visitors with suspected or confirmed COVID-19
Immediate isolation and referral for testing
Group patients with suspected or confirmed COVID-19 separately
Test all suspected patients for COVID-19
Safe clinical management
Immediate identification of inpatients and healthcare workers with suspected COVID-19
Adherence to IPC practices
Appropriate use of Personal protective equipment (PPE)
More detailed information regarding the IPC priorities for non-US healthcare settings can be found in the Strategic Priority IPC Activities for Containment and Prevention document.

Standard and Transmission-Based Precautions
Standard Precautions are a set of practices that apply to the care of patients in all healthcare settings at all times. Standard precautions remain the cornerstone of infection prevention. Application of these precautions depends on the nature of the health worker-patient interaction and the anticipated exposure to a known infectious agent. Standard precautions include:

Hand hygiene
Personal protective equipment
Respiratory hygiene and cough etiquette
Cleaning and disinfection of devices and environmental surfaces
Safe injection practices
Medication storage and handling
Transmission-based precautions are a set of practices specific for patients with known or suspected infectious agents that require additional control measures to prevent transmission. These precautions are used in addition to standard precautions.

COVID-19: Transmission-Based Precautions:
Current WHO guidance for healthcare workers caring for suspected or confirmed COVID-19 patients recommends the use of contact and droplet precautions in addition to standard precautions (unless an aerosol generated procedure is being performed, in which case airborne precautions are needed)1. Disposable or dedicated patient care equipment (e.g., stethoscopes, blood pressure cuffs) should be used; however, if equipment needs to be shared among patients, then it should be cleaned and disinfected between use for each patient (ethyl alcohol of at least 70%).

Additionally, adequately ventilated single rooms or wards are suggested. For general ward rooms with natural ventilation, adequate ventilation for COVID-19 patients is considered to be 60 L/s per patient. When single rooms are not available, suspected COVID-19 patients should be grouped together with beds at least 1 meter (3ft) apart based on WHO’s recommendations, although some member states, including the United States, have recommended maintaining greater distances whenever possible.iexternal icon COVID-19 isolation rooms or wards should have dedicated bathrooms, which should be cleaned and disinfected at least twice daily.

Additionally, healthcare facilities can also consider designating healthcare workers to care for patients with COVID-19 and restrict the number of visitors allowed in the facility.

Transportation of patients with COVID-19 should be avoided unless medically necessary. If a patient is deemed medically necessary to be transported, a mask should be placed on the suspected or confirmed COVID-19 patient. Healthcare workers should also wear the appropriate PPE when transporting patients.

Contact and droplet precaution PPE are recommended for healthcare workers before entering the room of suspected or confirmed COVID-19 patients. Healthcare workers should be trained on the correct use of PPE, including how to put on and remove PPE. Extended use and re-use of certain PPE items such as masks and gowns can be considered when there are supply shortages. Additional guidance can be located under Emergency Considerations for PPE. Healthcare workers should:

Use a medical mask (i.e., at least a surgical/medical mask)
Wear eye protection (goggles) or facial protection (face shield)
Wear a clean, non-sterile, long-sleeve gown
Use gloves
There is a higher risk of self-contamination when removing PPE. Please see instructions for putting on and removing PPE for guidance.

For healthcare workers performing any of the following aerosol generating procedures on patients with COVID-19, it is recommended that a fitted respirator mask (N95 respirators, FFP2 or equivalent) is used as opposed to surgical/medical masks. In addition to wearing a fitted respirator mask, healthcare workers should also wear appropriate PPE including gloves, a gown and eye protection.

Aerosol Generating Procedures include1:

Endotracheal intubation
Non-invasive ventilation
Manual ventilation before intubation
Cardiopulmonary resuscitation
Sputum induction
Autopsy procedures

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